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CASTA, the Cerebrolysin Acute Stroke Treatment in Asia trial, randomized 1,070 patients within twelve hours of an ischemic stroke to either 30 mL of cerebrolysin a day for ten days on top of aspirin, or to a saline placebo (Heiss et al., Stroke 2012, phase 3)

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With it, the compound achieves brain penetration seven times greater than BDNF and produces structural synaptic changes rather than temporary neurotransmitter modulation